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KMID : 0358420120550030158
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Korean Journal of Obstetrics and Gynecology
2012 Volume.55 No. 3 p.158 ~ p.165
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Association of genital Mycoplasmas infection in women who had preterm delivery and outcomes in premature infants
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Chung Hyun-Kyung
Park So-Yun
Park Mi-Hye
Kim Young-Ju
Chun Sun-Hee
Cho Su-Jin
Park Eun-Ae
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Abstract
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Objective: We conducted this study to evaluate the relationship between genital Mycoplasmas infection in women who had preterm delivery and the neontal outcomes.
Methods: We studied 116 women with preterm delivery (gestational age, ranged from 24 to 37 weeks) and their 116 premature infants born at Ewha Womans University Mokdong Hospital from August 2009 to December 2010. Culture for genital Mycoplasmas or a polymerase chain reaction was performed in vaginal fluid obtained from women who had preterm delivery. For perinatal outcomes, chorioamnionitis, funisitis and puerperal infection were analysed. We also evaluated the following neonatal data; birth weight, sex, small for gestational age, Apgar score, cord blood pH, ventilator care, hospital days, incidence of respiratory distress syndrome, bronchopulmonary dysplasia, sepsis, intraventricular hemorrhage and patent ductus arteriosus.
Result: Genital Mycoplasmas were isolated in 36.2% (42 of 116 patients). History of prior preterm birth was significantly higher and the cervical length at admission was significantly shorter in patients with genital Mycoplasmas infection (P < 0.05). Perinatal outcomes according to the Mycoplasmas infection and the neonatal outcomes were not statistically different between study and control groups. The relative risk of respiratory distress syndrome and bronchopulmonary dysplasia were 1.55 (95% confidence interval [CI], 0.65-3.70), and 1.24 (95% CI, 0.42-3.67), respectively.
Conclusion: There is higher incidence of prior preterm birth and shorter cervical length in patient with genital Mycoplasmas infection. However, genital Mycoplasmas infection does not affect the neonatal outcomes.
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KEYWORD
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Genital Mycoplasmas, Mycoplasma hominis, Ureaplasma urealyticum, Preterm birth, Premature infants
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